PReS-FINAL-2149: Interaction of PTPN2 and vitamin D GC sequence variants and risk of juvenile idiopathic arthritis
نویسندگان
چکیده
Introduction The causes of autoimmune diseases, including juvenile idiopathic arthritis (JIA) are presumed to involve the interplay of genes and environment. Vitamin D interacts with genes via vitamin D response elements (vdres). The gene PTPN2, associated with various autoimmune diseases including JIA, carries a VDRE and is regulated by vitamin D. Recently, an interaction between PTPN2 and VDR (vitamin D receptor gene) was reported for type 1 diabetes, such that disease association with VDR differed by PTPN2 genotype.
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